Refrigerated Probiotics

Probiotics are fragile microbes that need proper handling to maintain maximum potency and effectiveness. That’s why refrigerated probiotics are advisable for long-term storage. Although probiotic strains differ when it comes to heat sensitivity, most studies confirm that microorganisms eventually lose their growth and activity when kept at room temperatures. This process can create considerable quality issues to probiotic products that are sold unrefrigerated. If you are buying probiotic products that require refrigeration, whether online or at a grocery store, ensure that the manufacturer has refrigerated shipping to reduce heat exposure. Once you have popped open a container or removed a probiotic from a blister pack, use it immediately. Then, refrigerate to prolong shelf life. Probiotic products usually have these manufacturer recommendations.

Where do you buy refrigerated probiotics?

Wondering where to purchase refrigerated probiotic products? There are available ones you can get at your local supermarket, specialty food retailers, drug stores, and convenience shops. Just ask a sales clerk to point you in the right section. But the best way to score refrigerated probiotic products is to go and purchase them online.

Amazon has a wide array of probiotic products accompanied by reviews from customers. However, this is an online shopping site that harbors a selection of various brands and products. So, to narrow down your search, you need to scour the best health foods and supplement sources that carry probiotic products.

Here are some of the top three sites you can look into for your refrigerated probiotic requirement:


iHerb has been providing and selling nutritional products since 1996. It has a user-friendly online shopping platform where you can enter whatever you’re searching for such as ‘refrigerated probiotics’ in its search bar easily seen above the homepage. The site’s search engine will show refined results, and you can choose the type of refrigerated probiotic brand you like. iHerb is NSF International certified as a Good Manufacturing Practices (GMP) facility.


Vitacost is another popular e-platform that supplies discounted health and nutritional supplements. The best thing about the site is that it offers 100% money-back guarantee with any product they sell and provide. They will also offer a full refund or replacement. Similar to iHerb, Vitacost has a user-friendly search bar that you can type your search. Just key in ‘refrigerated probiotics’ see on top of the front page and quickly see and compare results.


eVitamins is your go-to source if you need to purchase a health supplement but want to save money. Just like iHerb and Vitacost, the eVitamins site has a search bar where you can type ‘refrigerated probiotics’ and quickly obtain results at reduced prices. eVitamins is a Better Business Bureau (BBB) and the NNFA (National Nutritional Foods Association) member.

Refrigerated Probiotics Brands

Now that you know where to buy refrigerated probiotics, here are some of the most popular and top-selling brands that require their probiotic products to be refrigerated. All of these products are kept chilled or freeze-dried upon delivery to preserve their freshness and potency.

Check out the list below and learn about their probiotic benefits:

Florajen Acidophilus Probiotics

Florajen Acidophilus Probiotics

Florajen Acidophilus is a high potency probiotic useful for maintaining and restoring vaginal flora, promoting intestinal health, and strengthening overall immunity. It doesn’t contain any preservatives, coloring, yeast, soy, corn, eggs, shellfish, or sugar. The suggested use for this product is to take one capsule on an empty stomach, preferably before breakfast or in between meals. This product should be kept in a fridge for maximum effectiveness.

  • 20 billion live cultures
  • Available in 30 and 60 capsules
  • Freeze-dried probiotic strain of live 100% Lactobacillus acidophilus
  • Maintains balance of vaginal flora
  • Promotes intestinal health
  • Boosts immune system

  • May cause constipation
  • May cause loose stool

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Flora Udo’s Choice Adult’s Blend Probiotics

Udo's Choice Children's Blend Probiotic

Flora Udo’s Choice Adult’s Blend Probiotic is for adults aged 55 years and above. This refrigerated product is designed to support digestion, boost immune function, and promote longevity and health in older adults. Each capsule contains 10 billion viable cells, and it’s best kept refrigerated.

  • 10 billion viable cells
  • Includes 7 Medical strains of senior-specific friendly bacteria
  • Comes in 60 capsules
  • Has higher percentage of Bifidobacteria than most typical adult formulas
  • Promotes health and wellbeing in seniors
  • Supports healthy microflora development in the small and large intestine
  • Boosts immune system

  • May cause constipation and bloating
  • Stomach discomfort

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Nature’s Way Primadophilus Bifidus

Nature's Way Primadophilus Kids

Primadophilus Bifidus by Nature’s Way is a probiotic product that ensures unfailing potency and delivery. The bottle contains 90 vegetarian capsules; these capsules should be in a fridge for maximum efficacy. Nature’s Way manufacturers store their products in a refrigerator then ship them in a cold pack, so the microorganisms are delivered alive when they arrive.  Suggested use is to take only one capsule daily in the morning, or as prescribed by a healthcare professional.

  • 5 billion CFUs
  • Comes in 90 vegetarian capsules
  • Strengthens general immunity
  • Boosts healthy digestion
  • Stimulates intestines
  • Balances microflora

  • May cause constipation and bloating

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These are only a few samples of refrigerated probiotics. Cold storage evidently increases the long-term survival of probiotic products, but there are indeed probiotics that don’t need refrigeration. However, when you have stumbled upon this non-refrigeration claim on a probiotic label, take it with caution unless the manufacturer can provide proof that show prolonged viability when kept at room temperature. Some probiotic products do contain probiotic strains that help in prolonging their shelf life such as Bacillus Coagulans (since they are spore-forming microorganisms and come as spores). However, some probiotic strains aren’t as effective as those that are well-researched like Lactobacillus and Bifidobacterium.

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